Since 2012, more and more researchers, companies and labs have worked on organ-on-a-chip technologies. They allow to perform cell cultures that can, thanks to microfluidics, mimic the cells’ microenvironment, such as the human body. Thus, these chips could become wonderful search accelerators and we hope that, in ten years, they could replace animal testing. Finally, OOCs could lead to the development of personalized medicine. This page gathers all the tutorials and reviews of Elveflow of this field.
Organ-on-a-chip review: Learn comprehensive basics with this state-of-the-art review of the field of organs-on-chips
Short review about organs-on-chips: Short on time? Read the short review!
Heart-on-a-chip: comprehensive review of heart-on-a-chip technology
Gut-on-a-chip: comprehensive review of gut-on-a-chip technology
Liver-on-a-chip: comprehensive review of liver-on-a-chip technology (with our thanks to the DeLIVER project)
Brain-on-a-chip: comprehensive review of brain-on-a-chip technology
Lung-on-chip history: how the lung on chip technology came to be developped, and the improvements that came to be
Short overview of lung-on-chip systems: special focus on reproducing the alveolar-capillary barrier thanks to microfluidic technology
Recent breakthroughs in lung-on-chip technology: stay up to date with the most recent developments in lung-on-chip technology
Lung on a chip model pack: a beta pack comprising our state-of-the-art instruments for an easy assembly of automated lung-on-a-chip models
Microfluidic tumor-on-a-chip systems for breast cancer research
Drug testing with OOC models: Comparison between organ-on-a-chip and standard in vitro and in vivo systems
Organs-on-chips companies
Organ-on-chip application pack
Gut-on-a-chip Pilot Pack
Endothelial cell culture Pilot Pack
Blood-brain barrier on a chip Pilot Pack
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Do you want tips on how to best set up your microfluidic experiment? Do you need inspiration or a different angle to take on your specific problem? Well, we probably have an application note just for you, feel free to check them out!
Exploring Organ-on-a-Chip Technology: A comprehensive review
Coronavirus (SARS-CoV2) diagnostic through microfluidics
In this report, we identify the following two main purposes for the 3D cell market
At the beginning of the third millennium, due to prolonged aging, neurodevelopmental disorders are growing and a much deeper understanding of the brain is necessary.
The liver is involved in more than 300 vital functions, but is mainly known for being part of the digestive tract, where it has the extremely important role of metabolizing both xenobiotics and nutrients (carbohydrates and lipids).
A heart-on-chip is a microfluidic chip reproducing the mechanisms of a heart, in order to test medicine quickly and observe the reaction of heart cells. Great care is given to mimic the mechanics of a heart in an artificial structure, lined with live heart cells.
While many animal models have been used to study lung diseases, they lack sufficient similarity with human systems, leaving gaps in what is possible in animal-based platforms.
The lung is the main organ of respiration whose function is to facilitate gas exchange in and out of the blood stream.
It could be extremely interesting to build a human-on-chip that will model the interactions between different organs, but it is also essential to develop simulations of tissue-tissue interfaces and more generally of local organ behavior.
Multi-organs on chip could also allow us to witness the side effects of certain drugs on different organs, not limited to those that the treatment targets.
Cell culture consists in growing cells in an artificial environment in order to study their behavior in response to their environment[1]. Different kinds of cell cultures can be found nowadays, and some would be more suited than others depending on its properties and applications.
Organ-on-chip companies developping innovative technologies
Although we take part in various research projects such as artificial photosynthesis, pathogen detection and stem cell differentiation, the ultimate goal of our entrepreneurial adventure is to accelerate anti-aging research.
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