Molecular machines for DNA repair : The DNAREPAIRMAN Project

Twelve European organizations coming from academia, coming from Netherland, Deutchland, France, United Kingdom and Poland will constitute a training and research network to study the DNA repair. The main idea behind the DNAREPAIRMAN Project is to understand some of  human critical DNA reparation pathway.

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Understanding the DNA repair pathways

In our body, we can count 1 million molecular lesions per cell per day. These lesions lead to DNA damage which can cause unregulated cell division and consequently tumor. To fight against these damages, DNA repair is constantly active and a deeply mechanistic understanding of its pathways is now fundamental. Indeed, the DNA repair ability of our cells is vital to the integrity of its  genome.

The relevance of this question has been recognized thanks to the 2015 Nobel Chemistry Prize, granted to three researchers focusing on DNA repair. Thus, the main goal of the DNAREPAIRMAN project is to perpetuate the virtuous cycle between new technologies, new questions and new insights.

The DNAREPAIRMAN Project goals

The DNAREPAIRMAN Projet gather scientists from three areas of research: biologists, chemists, and physicists, to answer a fundamental research question: what are the statistical properties and molecular mechanisms of the switches and motors involved in two critical DNA repair pathways?

Thus, the objectives of this consortium will be to characterize the mechanism of lesion formation, to determine the structure of the helicase recruitment complexes, to characterize the catalytic properties of the unwinding complexes, to understand the regulation of their activity and to establish the link between DNA repair and replication. To adress this challenge, Elvesys will develop a microfluidic platform which will be implemented at LMB and CNRS to multiplex single molecule light microscopy experiments.

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Guilhem Velvé Casquillas

Drop me a line

You have a research project in mind and you are looking for an industrial partner in microfluidics ?

I will study your proposition and come back to you quickly to find together the best way to collaborate on your project. If the submission deadline is coming soon,  I will try to come back to you on the same day.

Since all of us initially came from public research lab, we are used to collaborate with research laboratories inside scientific consortium and new scientific projects are always welcomed.

Feel free to write me and ask for Guilhem at:

Discover Elvesys microfluidic research projects

E-STEAM: A vape-healthy electronic cigarette

BlackHoleLab: Cheap as chips soft lithography station for any research laboratory

MEDLEM: Microfluidics fighting against Leukemia
FASTGENE VERSUS PATHOGENS: An epidemics tracking system

LAPASO’S EYE ON MALARIA: Quick and low-cost lab on a chip for malaria detection

Pillarcell: Microfluidic system for stem cell differentiation

Diflusel: Nanofluidic electro-concentration designed to replace ELISA assay

 The PHOTOTRAIN : Microfluidic for a sustainable future
THE DNAREPAIRMAN : Molecular machines for DNA repair
THE METABLE : Bioinformatics helping genome analyses



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