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Product catalog 2024
Trigger mechanical stimulus by adjusting confinement in real time
Allows advanced molecular and morphological analysis of confined cells
Enable the downstream analysis of cells
WHAT IS A BETA PACK?
Beta Packs, such as the Red Blood Cell Confinement Pack, are an assembly of instruments that include Elveflow’s catalog products and, at least, one beta product. The beta product has recently been developed by our Innovation team, and it is in testing phase. If you are interested in this beta pack, its applications, or possible variations to better fit your needs, contact our experts!
Credit: SEM of red blood corpuscles. David Gregory & Debbie Marshall. License: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Some of the situations in which RBC confinement occurs are in areas of the spleen and bone marrow. For example, in the spleen it acts as a blood filtration system as red blood cells can be temporarily confined in its narrow capillaries.
In that sense, a simulation model can be used to investigate hematological diseases. This is of great help as it will help with the development of treatments, medical devices and prevention of blood-related diseases.
Microfluidics will allow manipulation and control of well-defined and reproducible environments to confine red blood cells without causing excessive cell damage or deformation. Thus, microfluidics allows obtaining red blood cell behavior and interactions under conditions very similar to those in vivo.
Likewise, it favors real-time visualization and analysis to directly observe cell dynamics, deformability and responses to different flow conditions or stimuli. This allows the study of parameters such as cell velocity, adhesion, aggregation and mechanical properties. Also, microfluidic systems can be automated.
Thus, in red blood cell confinement, microfluidics can generate precise control of physiological conditions to study the confinement of red blood cells and explore their behavior, interactions and responses in a controlled and physiologically relevant environment.
We provide all the instruments to automate your fluidic setup. One of the possible configurations is shown in the following setup:
Red Blood Cell confinement pack includes:
Our beta pack for a Red Blood Cells confinement model includes all the components needed to set up a controlled model, including pumps, controllers, and software. We can advise you on the best chip as well, in case you don’t have a defined one yet. We also offer technical support and training to help researchers get started with their experiments.
Contact our experts to answer any questions about this pack and how it can match your specifications!
It is possible to analyze the change of the shape of red blood cells with respect to their vertical position under varying velocities. In that sense, experiments can be developed that allow you to evaluate how healthy red blood cells deform under the effect of friction imposed by the upper and lower walls. Some of the studies may help to understand what causes red blood cells to move away from the upper and lower walls toward regions.
Therefore, our system will help you to carry out your research by varying different parameters and adjusting it to your needs.
Elveflow provides a broad range of reservoirs, flow sensors, bubble detectors, traps, and other relevant instruments. All instruments are controlled by the same Elveflow software interface, enabling workflow automation and easy integration into your program using free available libraries.
– Check our other Beta Packs for various applications –
For any help to determine what microfluidic instruments you need, you can contact us! Our experts will help you build the best microfluidic setup for your application, with our state-of-the-art microfluidic line.
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