contact@elveflow.com+33(0).184.163.807+1(414)-406-4343 Elveflow is an Elvesys brand, an international microfluidics innovation center with high level researchers dedicated to microfluidics and organ-on-a-chip.
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Explore how microfluidics is revolutionizing cosmetic research from formulation to toxicology with ethical, precise, and scalable testing.
The photolithography mask is an important tool in soft photolithography processes, we explain here how they are made
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[2048x2048-height] => 618 ) ) ) [introduction_texte] => ) [principe] => Array ( [texte] => MONITOR THE MEASUREMENT OF ALL YOUR MICROFLUIDIC SENSORS Connect pressure and flow sensors wherever you want in the setup to closely monitor your microfluidic experiment. The Sensor Reader module allows you to control 4 sensors simultaneously. Additionally, our software allows controlling several Sensor Readers simultaneously. The MSR is the ideal supplement to the OB1 flow controller should you need high control over your experimental parameters. Benefit in an optimal manner from the performance of Elveflow® Sensors with the Sensor Reader acquisition interface. The open interface Sensor Reader also allows you to use third-party sensors. Fast and precise With an acquisition sampling rate of up to 200 Hz and an 16 bit resolution, the Sensor Reader allows you to easily conduct experiments involving monitoring or controlling a physical parameter with analog and digital sensors in real time. Wide sensors compatibility See Elveflow® fully compatible pressure sensor & flow sensor below Noise reduction An embedded analog 60 Hz low pass filter function can be activated on each channel independently to reduce sensor noise. PERFORMANCE Our Sensor Reader achieves an 16 bits resolution at up to 200 Hz sampling rate and a sub-resolution noise, for accuracy levels on your sensor measurements down to 0.05% of the full scale and a response time down to 5 ms. Sampling rate up to 200 Hz Resolution :from 9 to 16 bits Input range : 0 – 10 V Fully compatible with other Elveflow instruments Measurement noise below resolution Noise reduction function with a 3rd order 60 Hz low-pass filter ELVEFLOW® PRESSURE & FLOW SENSORS – FULLY COMPATIBLE We have already selected a wide range of integrated sensors fitting microfluidic applications. Flow Sensors (MFS) Resolution 1,5 pL/sec Ranges from 0.07 to 5000 μL/min Pressure Sensor (MPS & MFP) Accuracy down to 0.2 % of Full Scale 4 ranges from 5 psi (340 mBar) to 100 psi (7 bar) All our sensors are provided with an M8 electrical connection and can be used with the Sensor Reader. We also provide all the microfluidic connector kits necessary to start your experiment. [image] => ) [applications] => Array ( [texte] => Pressure sensor feedback loop How to study bacteria by microfluidics Controlled microfluidic sample injection Preparation of PLGA nanoparticles by flow focusing All our application notes: here! Mechanical cell compression Performance of polymeric skin adhesives during perspiration All our research summaries: here! Microfluidic for cell biology: Concepts and methodologies Thermoelectric sensor Microfluidics for point-of-care diagnostic devices All our reviews: here! Publications For all the publications using our products, please click here. For all the application notes and reviews based on our product, please click here. ) [specifications] => Array ( [texte] => The following table summarizes the main features of the Elveflow® MSR Microfluidic Sensor Reader. SENSOR READER UNIT SPECIFICATIONS Number of sensors connections up to 4 Sensor connectors M8 female (4 pins) USB reading current min – max 200 mA – 800 mA Sensor power supplies voltage 5 – 24 V Max total power per channel 0.9 W SENSOR INPUTS Impedance 1 MΩ Acquisition frequency 200 Hz Acquisition resolution from 9 to 16 bits Input range 0- 10 V Resolution (1 bit) 5 mV Noise (full band) 5 mV rms Compatible sensors Elveflow MFS flow sensor, MPS pressure sensor, MFP FlowPlus pressure sensor, MBD bubble detector, other sensors Non-contractual information, may be changed without notice SENSOR READER SIZE: without connectors (length x width x height): 91 x 69 x 29 mm WEIGHT: 320 g [image] => ) [download] => Array ( [fichiers] => ) [faq] => Array ( [items] => ) [more] => Array ( [more_title] => SOFTWARE [texte] => Software ESI is Elveflow’s more advanced software interface, built to make experimenter’s life better. It is perfectly adapted, from simple setups control to very advanced setups and workflows automation. It embarks several modules that make time-consuming and painful tasks so simple. It comes with SDK libraries to control the Elveflow system with your own code (C++, Python, MATLAB®, LabVIEW®) Sensor compatibility with MSR versions [image] => [video] => ) [outline1] => Array ( [text] => 1. ELVEFLOW’S SINGLE SOFTWARE (ESI) Monitor and automate your setup using our ESI software that allows you to measure, control and automate your experiment using only one interface. 2. FLOW SENSOR (MFS) OR PRESSURE SENSOR (MPS) Place the sensors anywhere you want on your fluidic path and electrically connect your sensors to the Microfluidic Sensor Reader. Thanks to their small footprint, sensors can be placed anywhere within your fluidic system. 3. MICROFLUIDIC SENSOR READER (MSR) Connect the sensor reader to your computer via USB and monitor it using the Elveflow® Smart Interface 4. CHIP / CAPILLARY Add you chip to complete the standard setup. In this position, the sensor directly measures the pressure entering the microfluidic chip. You can add another pressure sensor at the chip outlet in order to get the difference in pressure and/or the microfluidic resistance. [image] => ) [customization] => Array ( [title] => [] => [image] => [texte_1] => [texte_2] => [texte_3] => ) [outline2] => Array ( [image] => [text] => ) [produits_associes] => Array ( [0] => 375 [1] => 986 [2] => 1022 [3] => 985 ) [application_packs_on] => [software_on] => [distributors_on] => [services_on] => [citation_author_repeater] => [citation_publication_date] => [citation_keywords_repeater] => [description_GS] => [testimonials_prod] => [announcement_box] => [oem_product_banner] => Array ( [product_banner] => [product_title] => [product_description] => [button_label] => [button_url] => ) [ID] => 98351 [title] => Microfluidic sensor reader [permalink] => https://www.elveflow.com/microfluidic-products/microfluidics-flow-measurement-sensors/microfluidic-sensor-reader/ [post_type] => measurement [post_type_name] => Flow measurement ) ) )
An acquisition interface for all your sensors inside your setup
The Sensor Reader is an interface allowing the acquisition of many kinds of analog and digital sensors, including Elveflow’s pressure sensors and flow sensors. The Sensor Reader can be used to monitor flow rate, pressure, or other physical parameters on any type of flow control instrument (syringe pump, peristaltic pump, perfusion, pressure controller).
Connect pressure and flow sensors wherever you want in the setup to closely monitor your microfluidic experiment. The Sensor Reader module allows you to control 4 sensors simultaneously. Additionally, our software allows controlling several Sensor Readers simultaneously. The MSR is the ideal supplement to the OB1 flow controller should you need high control over your experimental parameters.
Benefit in an optimal manner from the performance of Elveflow® Sensors with the Sensor Reader acquisition interface. The open interface Sensor Reader also allows you to use third-party sensors.
Fast and precise
With an acquisition sampling rate of up to 200 Hz and an 16 bit resolution, the Sensor Reader allows you to easily conduct experiments involving monitoring or controlling a physical parameter with analog and digital sensors in real time.
Wide sensors compatibility
See Elveflow® fully compatible pressure sensor & flow sensor below
Noise reduction
An embedded analog 60 Hz low pass filter function can be activated on each channel independently to reduce sensor noise.
Our Sensor Reader achieves an 16 bits resolution at up to 200 Hz sampling rate and a sub-resolution noise, for accuracy levels on your sensor measurements down to 0.05% of the full scale and a response time down to 5 ms.
We have already selected a wide range of integrated sensors fitting microfluidic applications.
Flow Sensors (MFS)
Pressure Sensor (MPS & MFP)
All our sensors are provided with an M8 electrical connection and can be used with the Sensor Reader. We also provide all the microfluidic connector kits necessary to start your experiment.
For all the publications using our products, please click here.
For all the application notes and reviews based on our product, please click here.
The following table summarizes the main features of the Elveflow® MSR Microfluidic Sensor Reader.
Non-contractual information, may be changed without notice
SENSOR READER SIZE: without connectors (length x width x height): 91 x 69 x 29 mm WEIGHT: 320 g
ESI is Elveflow’s more advanced software interface, built to make experimenter’s life better. It is perfectly adapted, from simple setups control to very advanced setups and workflows automation. It embarks several modules that make time-consuming and painful tasks so simple. It comes with SDK libraries to control the Elveflow system with your own code (C++, Python, MATLAB®, LabVIEW®)
1. ELVEFLOW’S SINGLE SOFTWARE (ESI)
Monitor and automate your setup using our ESI software that allows you to measure, control and automate your experiment using only one interface.
2. FLOW SENSOR (MFS) OR PRESSURE SENSOR (MPS)
Place the sensors anywhere you want on your fluidic path and electrically connect your sensors to the Microfluidic Sensor Reader.
Thanks to their small footprint, sensors can be placed anywhere within your fluidic system.
3. MICROFLUIDIC SENSOR READER (MSR)
Connect the sensor reader to your computer via USB and monitor it using the Elveflow® Smart Interface
4. CHIP / CAPILLARY
Add you chip to complete the standard setup. In this position, the sensor directly measures the pressure entering the microfluidic chip. You can add another pressure sensor at the chip outlet in order to get the difference in pressure and/or the microfluidic resistance.
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MK4 ) [avantages] => Array ( [liste] => Array ( [0] => Array ( [icon] => icon-arrow-right [titre] => PRESSURE AND VACUUM CONTROL [texte] => Accurately control pressure to push and pull liquid ) [1] => Array ( [icon] => icon-arrow-right [titre] => FLOW CONTROL [texte] => Pair it with a flow sensor for accurate flow control ) [2] => Array ( [icon] => icon-arrow-right [titre] => UNMATCHED PERFORMANCE [texte] => High precision and responsiveness for your flow regulation ) [3] => Array ( [icon] => icon-check [titre] => MICROFLUIDIC AUTOMATION [texte] => Automate and control your microfluidic experiment ) ) ) [introduction_texte] => The OB1 allows you to control the output pressure of up to 4 channels independently, from -900 mbar to 8 bar, for a wide variety of advanced microfluidic applications. Thanks to our proprietary Piezoelectronic Technology, the OB1 MK3+ is 10 times more stable and up to 10 times faster than other microfluidic flow controllers. 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scientists for scientists, the versatile and powerful OB1 MK4 pressure controller provides the perfect flow control for all kinds of applications. Whether you need pressure or vacuum, low or high flow rate, for short or week-long processes and experiments, the OB1 MK4 is the ideal instrument for your microfluidic needs. Check out our OB1 animation here! The best performance on the market: Piezoelectric Technology The Elveflow OB1 MK4 is one of the best performing microfluidic flow control instruments worldwide that uses piezoelectric regulators. The piezoelectric technology gives you 20 times more precise and 10 times faster flow control than any other flow controller on the market. Customizable & upgradable: 1 module, up to 4 channels, 5 pressure & vacuum ranges available The OB1 MK4 can be configured according to your needs. In one piece of equipment, you can have up to 4 pressure and/or vacuum channels (and other customized options). If your needs change, the instrument can be upgraded later, in any way you want. Get the fastest flow rate control when paired with a flow sensor Connect the OB1 MK4 to a standard liquid flow rate sensor (MFS) or our premium Coriolis flow sensor (BFS, suitable for both liquid and gas) to directly control the flow rate in your chip. The system continuously calculates the pressure and maintains the desired and constant flow rate. Full control software, SDK, and UART communication Single and intuitive software to get started in a few clicks and automate complex and long experiments. The SDK libraries allow you to control the OB1 MK4 using your own code while connecting it to other instruments. The MK4 is also equipped with UART communication protocol in addition to the ESI and SDKs control, allowing it to communicate with most control systems, such as Mac, Linux, Arduino, PLC. OEM version available The OB1 MK4 can be used on a bench setup or embedded in your own product. Elveflow has a solution for every step of your research & development. Discover our OB1 MK4 OEM solution. [image] => ) [applications] => Array ( [texte] => Applications of Pressure-Driven Flow Control Thanks to its ultra-fast response time, high stability, and precise flow control, the OB1 pressure controller is a preferred choice for a wide range of liquid handling microfluidic applications, compared to syringe pumps or peristaltic pumps. Combined with precision flow sensors (like MFS or BFS), the OB1 pressure controller can accurately control flow rate in any microfluidic setups. Below is an overview of how pressure-driven flow control improves research across different domains. Droplet & Bead Generation Droplet Microfluidics Flow control microfluidics offers unmatched stability and responsiveness when generating monodisperse droplets in microchannels. The precise flow control is essential for the generation of identical droplets avoiding most post-synthesis steps. This monodispersity is essential in applications like digital PCR, single-cell analysis, or encapsulation. Explore droplet generation setup Alginate Bead Generation In biomedical research, alginate beads are used to encapsulate cells or molecules. Pressure-driven systems allow fine-tuned control over flow rates, ensuring uniform bead size and reliable encapsulation efficiency. See the alginate bead pack. Biology & Cell Culture Cell Perfusion Pressure-based perfusion ensures bubble-free, pulsation-free delivery of nutrients or drugs to cultured cells over extended periods, ideal for mimicking physiological flow conditions. Discover perfusion setup Organ-on-a-Chip Simulating organ-level responses on chips requires controlled fluid environments. Pressure-driven systems provide the accuracy and reactivity needed to replicate dynamic flow patterns and shear stress. Learn about Organ-on-a-Chip systems Cell Confinement Assays Experiments that study how cells adapt to physical constraints benefit from stable pressure control to reproducibly apply mechanical stress. See confinement assay example Cell Constriction Assays Revealing cellular responses to fibrotic environments or disease models requires reproducible deformation of cells, enabled by finely tuned pressure-controlled flows. View ischemia model example Cell Trapping & Synthetic Compartments Pressure-driven flows help trap and localize cells or materials in adapted microfluidic chips, useful in synthetic biology or compartmentalization studies. Read the synthetic cells study Flow Control & Mixin Sequential Injection & Mixing Delivering fluids in a precise sequence or generating on-chip gradients requires fast and programmable flow transitions. Pressure controllers enable seamless transitions between multiple fluid inlets. Explore the injection pack Recirculation Some in vitro assays require long term dynamic flow of reagents or cell culture media. In most cases it is essential to reuse the media, in order to mimic physiological conditions or avoid expenses. Using pressure-based flow control, one-way recirculation is possible to program for long term experiments.Learn about the recirculation setup Analytical Chemistry & Imaging Flow Chemistry Pressure-driven systems provide accurate reagent dosing and fast startup/shutdown, essential for reaction optimization in continuous-flow chemistry. This is particularly useful in the development of immunoassays and biosensors. See flow chemistry application Liquid-Phase Electron Microscopy (LPEM) Stable, pulseless flow is critical for imaging samples in real time at the nanoscale. Pressure control allows precise delivery of fluids during live-cell imaging under an electron beam, especially to study samples in their natural environment. Explore LPEM research Light-Field Flow Cytometry (LFC) In high-throughput single-cell analysis, stable and controlled flow conditions are key to accurate imaging and data capture. Pressure-based systems enable high-speed and consistent sample handling. Learn about 3D LFC Industrial Applications Enhanced Oil Recovery (EOR) Microfluidic chips simulating porous media allow researchers to visualize oil displacement mechanisms. Pressure control enables fine adjustment of flow to mimic subsurface conditions with high reproducibility. Read the full EOR review Cosmetic Formulation & Testing Microfluidics offers new possibilities for precision formulation of cosmetic emulsions and nano-encapsulation of active ingredients. Pressure-driven flow ensures reproducibility and scalability for testing stability, texture, or skin permeability on-chip. Explore cosmetic applications Integrated Systems Lab-on-a-Chip Platforms At the core of any lab-on-a-chip system is the need for precise, responsive, and stable flow control, features inherently supported by pressure-driven microfluidics. Whether it’s diagnostics, environmental sensing, or point-of-care testing, the OB1 system provides the control backbone required for success. Discover some lab-on-chip examples in this review Videos Publications For all publications featuring our products, please click here. For all application notes based on our product, please click here. For reviews of our product, please click here. ) [specifications] => Array ( [texte] => This table summarizes the main specifications of the Elveflow OB1 MK4 pressure controller. OB1 MK4 CHANNEL PRESSURE RANGE 0 to 200 mbar1 (0 to 2.9 psi) 0 to 2,000 mbar1 (0 to 29 psi) 0 to 8,000 mbar1 (0 to 116 psi) -900 to 1,000 mbar1 (-13 to 14.5 psi) -900 to 6,000 mbar1 (-13 to 87 psi) Pressure stability (2) 0.015% FS 30 µbar (0.0004 psi) 0.005% FS 100 µbar (0.0014 psi) 0.006% FS 500 µbar (0.007 psi) -900 to 500 mbar: 0.005% FS 100 µbar (0.0014 psi) 500 to 1,000 mbar: 0.007% FS 150 µbar (0.0021 psi) -900 to 2,000 mbar: 0.005% FS 350 µbar (0.005 psi) 2,000 to 6,000 mbar: 0.007% FS 525 µbar (0.008 psi) Response time (3) down to 10 ms Settling time (4) down to 50 ms Minimum pressure increment 0.006% FS 12 µbar – 0.00017 psi 0.006% FS 120 µbar – 0.0017 psi 0.006% FS 480 µbar – 0.007 psi 0.0064% FS 120 µbar – 0.0017 psi 0.0061% FS 420 µbar – 0.006 psi Pressure supply 1.5 bar to 10 bar Non corrosive, non explosive, dry and oil-free gases, e.g., air, argon, N2, CO2, … Input vacuum (5) / / / Any value from -0.7 to -1 bar Compatible with vacuum pump or vacuum line Any value from -0.7 to -1 bar Compatible with vacuum pump or vacuum line Liquid compatibility Non contact pump Any aqueous, oil, or biological sample solution. Non-contractual information, may be changed without notice (1) Max pressure value might vary by +/- 2.5% (2)Pressure stability (standard deviation) measured over the full pressure range with an external high accuracy pressure sensor (Druck DPI150) (3) Time required to reach 5% of the setting point. Depends on the computer operating system (4) Time required to reach 95% of the set point. Volume dependent – Measurement was done on 12 mL reservoir for a set point from 0 to 200 mbar (5) A vacuum source is mandatory for calibration and use of dual channels even if the channels are to be used in pressure only Flow control Flow sensor compatibility Compatible with the whole MFS and BFS range Monitoring and feedback loop flow control available Flow rates From 0,1 µL/min to 500 mL/min (indicative, please refer to the MFS and BFS series) Liquid compatibility Non-contact pump Any aqueous, oil, or biological sample solution. Control & monitoring Software control Elveflow Smart Interface – Windows 7, 8, 10, both 32 and 64 bit versions supported Software Development Kit Libraries available: Matlab, Python, LabView, C++ – Windows 7 & 10, both 32 & 64 bit versions supported Serial/UART communication protocol on request Data management Possibility to log and extract data (CSV): channel and sensor detailed information using ESI Input profiles Possibility to load profiles: ramp, sine, triangle, square, or custom Automation Generate step-by-step sequences using the ESI built-in sequence management Log and export custom configurations (CSV) Screen LCD screen showing pressure and sensor flow rate in real time Electrical Specifications Input Voltage (V) 24V Typical Power (W) 12W Provided Power Supply Specifications Supply Voltage Range (V): 100 to 240 VAC Supply AC Frequency (Hz): 50 to 60 Hz Maximum Output Current (A): 1.5 A Maximum Output Power (W): 36W Interface USB Type B Communication Type Serial Software Control ESI Sensor Connection One M8 4-pins connector per channel Compatibility Elveflow sensors: MFS, MPS, MFP, MBD Custom sensors: 5 to 24V supply voltage, 0 to 10V readout voltage Triggers Input and Output TTL signal 0V or 5V Other Casing dimensions (length x width x height): 240 x 223 x 80 mm Weight 1.4 kg to 2.9 kg Non-contractual information, may be changed without notice [image] => ) [download] => Array ( [fichiers] => ) [faq] => Array ( [items] => Array ( [0] => Array ( [question] => What pressure range should I choose? [reponse] => The performances of the OB1 (for example, the pressure stability) is tied to the full operating pressure range. In order to achieve optimum performance, we recommend our users to choose the smallest pressure range that covers the required experimental pressures. ) [1] => Array ( [question] => Can I achieve direct flow control? [reponse] => By coupling a MFS or BFS flow sensor to the OB1 flow controller, you can use the software to directly control the flow rate by directly inputting the flow rate value. The software uses a PID loop to control the flow rate by setting automatically the pressure to reach the requested flow rate. Doing so, you can benefit of the best of the two worlds to get a fast and precise (pressure driven) volume flow rate (flow sensor). ) [2] => Array ( [question] => Can I connect a Pressure Sensor to the OB1? - [reponse] => Pressure and flow sensors can be connected directly to the OB1 MK4. The sensors can be used in passive mode (for monitoring only) or active mode (to enslave). ) [3] => Array ( [question] => Do I need a pressure and/or vacuum source to operate the OB1 Pressure controller ? [reponse] => Yes, you will need a pressure source to work with the OB1 pressure controller. You can either use the air supply of your lab if there is one, use a compressed air bottle or use an air compressor. Elveflow has selected a compressor that is perfectly fitted for most application using the OB1. If your OB1 has a vacuum channel, you will need a vacuum pump. Elveflow also proposes a selected pump that work perfectly with the OB1. ) [4] => Array ( [question] => How to install the OB1? [reponse] => Click here Unboxing video ) ) ) [more] => Array ( [more_title] => Software [texte] => Software ESI is Elveflow’s dedicated software interface, built to make life easier for experimenters. It is perfectly adapted for the control of simple and complex setups and workflow automation. It integrates several modules that make time-consuming and painful tasks simple. It comes with SDK libraries to control the Elveflow system from your own code. The OB1 control window allows to:
The OB1 allows you to control the output pressure of up to 4 channels independently, from -900 mbar to 8 bar, for a wide variety of advanced microfluidic applications.
Thanks to our proprietary Piezoelectronic Technology, the OB1 MK3+ is 10 times more stable and up to 10 times faster than other microfluidic flow controllers.
Designed by scientists for scientists, the versatile and powerful OB1 MK4 pressure controller provides the perfect flow control for all kinds of applications. Whether you need pressure or vacuum, low or high flow rate, for short or week-long processes and experiments, the OB1 MK4 is the ideal instrument for your microfluidic needs.
Check out our OB1 animation here!
The Elveflow OB1 MK4 is one of the best performing microfluidic flow control instruments worldwide that uses piezoelectric regulators. The piezoelectric technology gives you 20 times more precise and 10 times faster flow control than any other flow controller on the market.
The OB1 MK4 can be configured according to your needs. In one piece of equipment, you can have up to 4 pressure and/or vacuum channels (and other customized options). If your needs change, the instrument can be upgraded later, in any way you want.
Connect the OB1 MK4 to a standard liquid flow rate sensor (MFS) or our premium Coriolis flow sensor (BFS, suitable for both liquid and gas) to directly control the flow rate in your chip. The system continuously calculates the pressure and maintains the desired and constant flow rate.
Single and intuitive software to get started in a few clicks and automate complex and long experiments. The SDK libraries allow you to control the OB1 MK4 using your own code while connecting it to other instruments. The MK4 is also equipped with UART communication protocol in addition to the ESI and SDKs control, allowing it to communicate with most control systems, such as Mac, Linux, Arduino, PLC.
The OB1 MK4 can be used on a bench setup or embedded in your own product. Elveflow has a solution for every step of your research & development. Discover our OB1 MK4 OEM solution.
Thanks to its ultra-fast response time, high stability, and precise flow control, the OB1 pressure controller is a preferred choice for a wide range of liquid handling microfluidic applications, compared to syringe pumps or peristaltic pumps. Combined with precision flow sensors (like MFS or BFS), the OB1 pressure controller can accurately control flow rate in any microfluidic setups. Below is an overview of how pressure-driven flow control improves research across different domains.
Droplet Microfluidics Flow control microfluidics offers unmatched stability and responsiveness when generating monodisperse droplets in microchannels. The precise flow control is essential for the generation of identical droplets avoiding most post-synthesis steps. This monodispersity is essential in applications like digital PCR, single-cell analysis, or encapsulation. Explore droplet generation setup
Alginate Bead Generation In biomedical research, alginate beads are used to encapsulate cells or molecules. Pressure-driven systems allow fine-tuned control over flow rates, ensuring uniform bead size and reliable encapsulation efficiency. See the alginate bead pack.
Cell Perfusion Pressure-based perfusion ensures bubble-free, pulsation-free delivery of nutrients or drugs to cultured cells over extended periods, ideal for mimicking physiological flow conditions. Discover perfusion setup
Organ-on-a-Chip Simulating organ-level responses on chips requires controlled fluid environments. Pressure-driven systems provide the accuracy and reactivity needed to replicate dynamic flow patterns and shear stress. Learn about Organ-on-a-Chip systems
Cell Confinement Assays Experiments that study how cells adapt to physical constraints benefit from stable pressure control to reproducibly apply mechanical stress. See confinement assay example
Cell Constriction Assays Revealing cellular responses to fibrotic environments or disease models requires reproducible deformation of cells, enabled by finely tuned pressure-controlled flows. View ischemia model example
Cell Trapping & Synthetic Compartments Pressure-driven flows help trap and localize cells or materials in adapted microfluidic chips, useful in synthetic biology or compartmentalization studies. Read the synthetic cells study
Sequential Injection & Mixing Delivering fluids in a precise sequence or generating on-chip gradients requires fast and programmable flow transitions. Pressure controllers enable seamless transitions between multiple fluid inlets. Explore the injection pack
Recirculation Some in vitro assays require long term dynamic flow of reagents or cell culture media. In most cases it is essential to reuse the media, in order to mimic physiological conditions or avoid expenses. Using pressure-based flow control, one-way recirculation is possible to program for long term experiments.Learn about the recirculation setup
Flow Chemistry Pressure-driven systems provide accurate reagent dosing and fast startup/shutdown, essential for reaction optimization in continuous-flow chemistry. This is particularly useful in the development of immunoassays and biosensors. See flow chemistry application
Liquid-Phase Electron Microscopy (LPEM) Stable, pulseless flow is critical for imaging samples in real time at the nanoscale. Pressure control allows precise delivery of fluids during live-cell imaging under an electron beam, especially to study samples in their natural environment. Explore LPEM research
Light-Field Flow Cytometry (LFC) In high-throughput single-cell analysis, stable and controlled flow conditions are key to accurate imaging and data capture. Pressure-based systems enable high-speed and consistent sample handling. Learn about 3D LFC
Enhanced Oil Recovery (EOR) Microfluidic chips simulating porous media allow researchers to visualize oil displacement mechanisms. Pressure control enables fine adjustment of flow to mimic subsurface conditions with high reproducibility. Read the full EOR review
Cosmetic Formulation & Testing
Microfluidics offers new possibilities for precision formulation of cosmetic emulsions and nano-encapsulation of active ingredients. Pressure-driven flow ensures reproducibility and scalability for testing stability, texture, or skin permeability on-chip. Explore cosmetic applications
Lab-on-a-Chip Platforms At the core of any lab-on-a-chip system is the need for precise, responsive, and stable flow control, features inherently supported by pressure-driven microfluidics. Whether it’s diagnostics, environmental sensing, or point-of-care testing, the OB1 system provides the control backbone required for success. Discover some lab-on-chip examples in this review
For all publications featuring our products, please click here.
For all application notes based on our product, please click here.
For reviews of our product, please click here.
This table summarizes the main specifications of the Elveflow OB1 MK4 pressure controller.
(1) Max pressure value might vary by +/- 2.5% (2)Pressure stability (standard deviation) measured over the full pressure range with an external high accuracy pressure sensor (Druck DPI150) (3) Time required to reach 5% of the setting point. Depends on the computer operating system (4) Time required to reach 95% of the set point. Volume dependent – Measurement was done on 12 mL reservoir for a set point from 0 to 200 mbar (5) A vacuum source is mandatory for calibration and use of dual channels even if the channels are to be used in pressure only
The performances of the OB1 (for example, the pressure stability) is tied to the full operating pressure range.
In order to achieve optimum performance, we recommend our users to choose the smallest pressure range that covers the required experimental pressures.
By coupling a MFS or BFS flow sensor to the OB1 flow controller, you can use the software to directly control the flow rate by directly inputting the flow rate value.
The software uses a PID loop to control the flow rate by setting automatically the pressure to reach the requested flow rate. Doing so, you can benefit of the best of the two worlds to get a fast and precise (pressure driven) volume flow rate (flow sensor).
Pressure and flow sensors can be connected directly to the OB1 MK4. The sensors can be used in passive mode (for monitoring only) or active mode (to enslave).
Yes, you will need a pressure source to work with the OB1 pressure controller.
You can either use the air supply of your lab if there is one, use a compressed air bottle or use an air compressor. Elveflow has selected a compressor that is perfectly fitted for most application using the OB1.
If your OB1 has a vacuum channel, you will need a vacuum pump. Elveflow also proposes a selected pump that work perfectly with the OB1.
Click here
Unboxing video
ESI is Elveflow’s dedicated software interface, built to make life easier for experimenters. It is perfectly adapted for the control of simple and complex setups and workflow automation. It integrates several modules that make time-consuming and painful tasks simple. It comes with SDK libraries to control the Elveflow system from your own code.
The OB1 control window allows to:
For more details about Pressure driven flow control, please read this application note.
By connecting a MFS or BFS Flow Sensor to the OB1 MK4, you enable direct rapid and precise regulation of the flow rate. The PID algorithm of the software reads the flow rate and adjusts the pressure accordingly to reach the target flow rate with speed and precision.
We have several pressure channel options available covering a wide range, up to 8000 mbar (116 PSI) and down to -900 mbar (-13 PSI). Choose the pressure channel that covers your experimental pressure requirements.
The OB1 MK4 is a compact module that can accommodate up to 4 channels (pressure and/or vacuum). Each module can be upgraded at any time and have channels added or changed. You can control as many channels as you want with one computer.
Need more channels on one module (8, 16, 64…. or even more)? Our custom service would design a specific pressure controller that fits your needs.
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