Droplet-based microfluidics is an emerging technology based on hydrodynamics principles: fluids are handled in a precise and reliable manner, providing essential tools to miniaturize and automatize assays.
Traditionally, particles, nanoparticles and emulsions are formed by batch method: eg. using high shear methods such as sonication or homogenizers. These methods can produce large amounts of material, and can be quite simple to use. However, particles are (very) polydisperse, so filtering etc. is often needed. High shear stress can also cause problems, eg. with encapsulated payload.
Droplets formed within microfluidic channels often serve as microreactors containing different chemical or biological compounds, allowing massive numbers of independent reactions to be performed rapidly using a minimal amount of total reagent.
Microfluidic methods offer a number of significant advantages:
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To make droplets in microfluidics, you will need:
For historical reasons, a syringe pump is the most used system in microfluidics. However, researchers are starting to switch to pressure control systems because their unique performances enhance experiments. Pressure-driven flow control allows pulseless flow within subsec response time. It consists in using a gas input pressure within a hermetic liquid tank in order to flow liquid from the tank to your microfluidic device.
A pressure controller pressurises a reservoir containing the sample, causing it to be pushed out through capillary tubing. A flow sensor placed just before the chip measures the flow, and feeds it back to the software, which then regulates the pressure applied to the reservoir to maintain a smooth flow.
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It brings the many benefits of microfluidics, such as excellent monodispersity, reproducibility and scalability, to your daily work in order to achieve great science.
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Do you want tips on how to best set up your microfluidic experiment? Do you need inspiration or a different angle to take on your specific problem? Well, we probably have an application note just for you, feel free to check them out!
This review gathers a collection of information regarding liposome and lipid nanoparticle from their use and applications to how to generate them by bulk
Brief overview of the numerous advantages of confined particles like bubbles, droplets and fibers and how confinement can be used for various applications
The review summarizes the various droplet production methods available from microfluidics to the more commun batch method.
This review focuses on sodium alginate and its applications in microfluidics
Making droplets in a capillary or a microfluidic device is often met with two problems
Microfluidic technologies offer an efficient means of producing highly uniform droplets and bubbles, and also a convenient mechanism for manipulating their downstream motion.
Digital microfluidics is an alternative technology for microfluidic systems based on the design, composition and manipulation of discrete droplets and/or bubbles.
Drop-Seq is a strategy based on the use of microfluidics for quickly profiling thousands of individual cells simultaneously by encapsulating them in tiny droplets for parallel analysis. This review presents the techniques and applications of Drop-Seq.
Droplet generation in microfluidic, the aim of this technology is to create fluid-fluid dispersion into channels
It is possible to make droplets in a microfluidic capillary with commercial tools, especially chromatography tools. One can easily make droplets...
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