AutoMonoDroplet: Development of a commercially-viable system for the automatic generation of high-throughput well-defined microdroplets

Emulsions of microdroplets (suspensions of micrometer-sized droplets in an immiscible medium) are used in a wide range of applications especially in pharmaceutical and biosciences, beauty and food industries.

AutoMonoDroplet-Elveflow-Elvesys

Using conventional techniques, it is difficult to control the size distribution of the resulting droplets, which may affect rate of the droplet degradation, the kinetics of encapsulant release, and decrease the stability of the emulsion. This is particularly problematic in the pharmaceutical industry, where irregular drug quantities encapsulated in polydisperse drug-loaded droplets and particles can cause an initial burst of drug release in vivo, which eventually can lead to undesirable cytotoxic effects.

In this project we are developing fully automated droplet production system, which can monitor droplet size, adjust flow rates and pressures of the liquids to compensate for any changes in the droplet production system and to maintain very high droplet production uniformity (C.V. < 0.2%) for long periods of time at the same time producing high amounts of monodisperse emulsions.

This system will give ELVESYS the highest competitive advantage on a global total admissible market of €3.5 billion per year by 2025. This PoCT is today the key solution to alleviate the medical and social issues of ocular diseases that weighs more than €86 billion annually on the EU healthcare systems. This project will also allow ELVESYS to train me in entrepreneurship so that I can later become part of the team or start their own spin-off company to commercialize the PoCT system developed.

REMIGIJUS-VASILIAUSKAS-elveflow-microfluidics

Researcher

Dr. Remigijus Vasiliauskas

Research Associate

  • R&D Engineer in Digital Microfluidics
  • Post-Doc in Digital Microfluidics and Drug Delivery (Vilnius University, Lithuania)
  • PhD in Physics (Linkoping University, Sweden)
  • Master of Science in Material Sciences (Vilnius University, Lithuania)
  • 27 publications, 320 citations, h-index 12

 

Areas of expertise: Digital Microfluidics, Microtechnology, Soft Litography, Semiconductor Technology and Sensors.

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