Flow Chemistry - Microfluidics and sample preparation

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PULSATION FREE

Perfectly stable flow rate during your experiments

CONTROLLED CONCENTRATION OF EACH REAGENT

Change concentration of each sample

Setup automation

Schedule your tests for days

The advent of microfluidics as a tool for chemical synthesis is coming of age, particularly in industrial techniques. It has many advantages over conventional techniques such as as small reagent consumption, improved selectivity, less strigent reaction clean up, rapid reactions and small footprints.

High stability

Ensure a perfect control over your flow rate

High-throughput sample processing

Screen a large range of variables. Suited for production.

Lower reagent costs

40ms settling: lowers the loss of expensive samples

Setup Automation

Create your own sequence

Applications

  • Polymer synthesis
  • Organic synthesis
  • In-chip reagant mixing
  • Manufacturing complex
  • Green chemistry
  • Drug discovery
  • Sample preparation
  • Drug screening

Flow Chemistry Set-up

A fluidic system dedicated to Flow chemistry

Elveflow® provides a unique system dedicated to Flow chemistry and sample preparation. This fully integrated solution includes all the necessary elements to create a continuous flow and monitor flow rate.

Mix between 18 different reagents

For experiments requiering mixing different components in different amounts.

Using two 11 ports / 10 positions valves it is possible to mix up to 18 different reagents (one vial for each selector valve being needed for the washing sequence). The use of the Microfluidic Coriolis Flow sensor ensures a fine control for mass injection and to finely tune the ratio of the different liquid injected. Then, the use of a 3/2 valve at the outlet of the chip allow to direct the output of the mixing chip either to a waste for the washing step of the the collection vial for the coumpound of interest.

Reactor – Mixing chip

With regards to Microfluidic Mixers you can take a look to the following review or contact our team for advices.

Flow chemistry pack with OB1 MUX distributor Bronkhorst Valves and software

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The above video showcases the stability of the controller. We are injecting three different liquids inside a channel and perfectly tuning the ratio of different the different liquids.

It is particularly usefull for the applications mentionned earlier.

2-2 Valve
2-2 Valve
3-2 Valve
Micromixer - Chip used to mix fluids
Bronkhorst Flow Controller 1
Bronkhorst Flow Controller 2
OB1 Pressure Controller 2 Channels
MUX Distributor 2
MUX Distributor 1

Benefits

  • Small vials for expensive samples
  • Large vials for long term experiment
  • Disposable parts
  • Washing steps (no cross contamination)
  • Modular, Upgradable and scalable
  • 0.2% accuracy for flow injection
  • Automate injection
  • Small footprint
  • High chemical compatibility (PEEK, Stainless steel)

Conclusion

Microfluidics has a lot of advantages over conventional techniques for flow chemistry and sample prepation. It paves the way to new applications and better control.

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