Organ-on-chip for personalised and generalised integrated biomaterial risk assessment : the PANBioRA Project
Lots of medical devices, like implants, coronary stents or fracture pins, are made of biomaterials.
The biological evaluation of new biomaterials are currently time and resource consuming. Moreover, once implanted, biomaterial devices often lead to complications such as inflammation or infections, showing the difficulty to assess their innocuity and the importance of developing new tools for personalised pre-implantation diagnostics.
The goal of PANBioRA is to provide a set of tools to standardize evaluation of new biomaterials. The same platform should also allow personal testing of different materials to assess the risks and choose the most appropriate for each patient.
Among this consortium of 17 partners spread across 11 countries, Elvesys is going to share its expertise in microfluidics to help developing this new set of tools.
The evaluation of biomaterials will be based on various factors, one of which is through the use of organs-on-chips to mimic the key barriers of the body. Elvesys is in charge of optimizing devices for organs-on-chips production, by testing and comparing different materials for the chips: widely studied PDMS, thermopolymers such as PS, PC or PMMA, classically used by biologists, and the innovative material FlexdymTM developed by our sister company Eden Microfluidics. This last material is of high interest for cell culture: its chemical composition and its formulation make it a perfectly biocompatible material and its self-adhesive properties allow very simple and flexible assembly of organ-on-chip.
A second step will be the design and the construction of a cartridge connecting all organ-on-chip modules together.
FlexdymTM material used for designing organ-on-chip