Organ-on-chip for Early Molecular Diagnostic of Schizophrenia: the SZ-test project

Schizophrenia is a severe mental disorder affecting more than 24 million people in the world.

SZ-test_organ-on-chip_Elvesys_schizophrenia1Image credit: vector designed by Rawpixel –

There is currently no medical test to confirm this disease, and no cure. Available treatments are often inefficient and may cause severe side effects. Molecular mechanisms at the origin of schizophrenia are not fully understood yet, making difficult the development of effective treatments.

The aim of this project is to decipher schizophrenia at a molecular level, and to identify new relevant biomarkers to elaborate performant diagnostic tools, allowing early stage detection and better disease management.

In this consortium of 9 partners, Elvesys is bringing its expertise on cell culture in microfluidics devices, in particular for the design of organs-on-chips. Microfluidic equipment developed by our brand Elveflow®, and more specifically our pressure controller and our flow multiplexer, will allow to tune very precisely the environment of the cells, and to be as close as possible to the in-vivo reality.

This work should be further developed in the future since the consortium applied for two other European calls.


Image credit: vector designed by Rawpixel –

This project has received funding from the European Union’s Horizon 2020 MSCA-RISE under grant agreement No 734791 (SZ-test project).


Guilhem Velvé Casquillas

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