AutoDropProd: Automated high-throughput production of monodisperse emulsions with microfluidics
Monodisperse emulsions are of great interest for food industry, pharmaceutical industry and cosmetics industry as they have an increased stability and better controlled properties compared to the polydisperse ones.
Thanks to the success of AutoMonoDroplet project, we are now able to automatize the production of specific size droplets at rates higher than 5 kHz in microfluidics chips and to precisely control their size, making monodisperse emulsions with a coefficient of variation below 0.2%. This is achieved by measuring the droplet size using optical methods based on our Optoreader and constantly adjusting the droplet diameter by changing flow rates and pressures. To achieve the best results we are using the fast response Elveflow flow control system, thus improving the performance of the system.
The production of monodisperse emulsions in a single channel is already well controlled, thus we will concentrate in this new project on the high-volume droplet production to meet industrial needs. We aim to apply parallelized droplet generators in combination with controlled automated droplet production to provide monodisperse emulsions despite any fluctuations in the system (for example the clogging of a microfluidic channel or other instabilities).
Additionally, when using the combination of our developed system with an adjustable chip geometry, one can produce droplets of almost any desirable size using single chip, thus avoiding droplet size limitation imposed by the channel dimensions.
As a result, we will be able to offer a very versatile, stable and simple to use microfluidic system to perform the generation of specific size monodisperse emulsions at an industrial scale.
Dr. Remigijus Vasiliauskas
- R&D Engineer in Digital Microfluidics
- Post-Doc in Digital Microfluidics and Drug Delivery (Vilnius University, Lithuania)
- PhD in Physics (Linkoping University, Sweden)
- Master of Science in Material Sciences (Vilnius University, Lithuania)
- 27 publications, 320 citations, h-index 12
AREAS OF EXPERTISE: Digital Microfluidics, Microtechnology, Soft Lithography, Semiconductor Technology and Sensors