Molecular machines for DNA repair : The DNAREPAIRMAN Project
Twelve European organizations coming from academia, coming from Netherland, Deutchland, France, United Kingdom and Poland will constitute a training and research network to study the DNA repair. The main idea behind the DNAREPAIRMAN Project is to understand some of human critical DNA reparation pathway.
Understanding the DNA repair pathways
In our body, we can count 1 million molecular lesions per cell per day. These lesions lead to DNA damage which can cause unregulated cell division and consequently tumor. To fight against these damages, DNA repair is constantly active and a deeply mechanistic understanding of its pathways is now fundamental. Indeed, the DNA repair ability of our cells is vital to the integrity of its genome.
The relevance of this question has been recognized thanks to the 2015 Nobel Chemistry Prize, granted to three researchers focusing on DNA repair. Thus, the main goal of the DNAREPAIRMAN project is to perpetuate the virtuous cycle between new technologies, new questions and new insights.
The DNAREPAIRMAN Project goals
The DNAREPAIRMAN Projet gather scientists from three areas of research: biologists, chemists, and physicists, to answer a fundamental research question: what are the statistical properties and molecular mechanisms of the switches and motors involved in two critical DNA repair pathways?
Thus, the objectives of this consortium will be to characterize the mechanism of lesion formation, to determine the structure of the helicase recruitment complexes, to characterize the catalytic properties of the unwinding complexes, to understand the regulation of their activity and to establish the link between DNA repair and replication. To adress this challenge, Elvesys will develop a microfluidic platform which will be implemented at LMB and CNRS to multiplex single molecule light microscopy experiments.
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